[3] A small-form-factor version of the Z200, along with Intel Westmere Xeon processor refresh, were introduced to the lineup in March 2010.

[6] The second-generation workstations Z820, Z620 and Z420 were announced in March 2012, featuring Intel Sandy Bridge-EP Xeon E5 processors.

[14][15] The fourth-generation workstations Z8 G4, Z6 G4 and Z4 G4 were announced in September 2017, shipping with Intel Skylake first-generation Xeon Scalable or W-series processors.

[17] Entry-level Z2 G4 and Z2 Mini G4 were announced in July 2018, featuring Intel Coffee Lake Xeon E-2100 processors.

The HP Z4 G5 edition features a new workstation-specific Sapphire Rapids CPU family, the single-socket Intel Xeon W-2400 Series, available with 6 to 24 cores.

It supports twice as much memory as the Z6 and Z8 and up to four double-width GPUs, which is of interest to those pushing the boundaries of GPU rendering, AI, or simulation, and has several server-grade features.