2L58, 2L5B873912123ENSG00000135116ENSMUSG00000046607O00198P62816NM_003806NM_007545NP_003797NP_031571Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.

The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK.

HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS.

HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.

This article on a gene on human chromosome 12 is a stub.