Hadjer-Lamis (Arabic: حجر لميس) is one of the 23 regions of Chad, located in the southwest of the country.

The far north-west of the region borders on Lake Chad.

Massakory is the regional capital; other major settlements include Bokoro, Gama, Karal, Massaguet, Moïto, N'Djamena Fara and Tourba.

[1] Per the census of 2009, the total population in the region was 562,957, 50.1% females.

[2] The main ethnolinguistic groups are (generally kanembou), Buduma, Dazaga Tubou, Kanuri, Malgbe, Baggara Arabs, and Mpade.