Mayo-Kebbi Ouest (Arabic: مايو كيبي الغربية) is one of the 23 regions of Chad.

It is composed of the southern areas of the former prefecture of Mayo-Kebbi (sub-prefectures of Pala and Léré).

The Mayo Kébbi river flows through the north the region, with Lake Léré and the smaller Lake Tréné located in the north-west.

[2] Palais the regional capital; other major settlements include Binder, Guégou, Lagon, Lamé, Léré and Torrock.

[1] The main ethnolinguistic groups are the Fula, Gidar, Mangbai, Mundang, Ngeté-Herdé peoples, Peve, Sara groups such as the Ngambay, and Tupuri.