John Hagan Pryce Bayley FRS, FLSW (born 13 February 1951[3]) is a British scientist, who holds the position of Professor of Chemical Biology at the University of Oxford.
[12] Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins,[13] as well as interests in chemical signal transduction and biomolecular materials.
[14] He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha haemolysin[15] engineered for sensing has been highly cited.
These studies have led to the development of protein pores as "nanoreactors", with which both non-covalent and covalent chemistry of single molecules can be examined.
Based on this work, Bayley has developed "stochastic sensing," which has been shown with a wide variety of analytes to reveal both concentration and identity through single-molecule detection.