Hagia Sophia of Mystras was made back into a Christian church when Greece achieved independence during the early nineteenth century.

Hagia Sophia was built in the fourteenth century by the first despot of Mystras, Manuel Kantakouzenos, whose monograms are preserved on marble plaques of the church.

[1][2] The church was originally dedicated to Jesus Christ the Life Giver (Ancient Greek: Ζωοδότης Χριστός, romanized: Zoodotes Christos)[2] and was the catholicon of the men's monastery, bearing the same name, as can be seen from the seal of the Patriarch of Constantinople Philotheus, from the year 1365, with which it was converted into a monastery at the request of the founder himself.

In 1989 Hagia Sophia along with the rest of the ruins, fortress, palace, churches, and monasteries of Mystras, was named a UNESCO World Heritage Site.

[2] The elaborate decoration of the interior of the church is complemented by marble inlays; the two columns to the west and the older architrave, dating to the twelfth century, of the iconostasis, only portions of which remain to this day.