The site on which the current temple stands built has been sacred since ancient times, that is, long before Christ.

[1] During the Venetian rule of Patras in the fifteen century it was converted into a Catholic church and re-dedicated to Saint Mark.

"[3] At the beginning of the Greek War of Independence in 1821, it was said that thet first bullets that fell in Patras against the Ottomans were made with lead taken from the dome of the mosque.

[1] After Greece achieved independence from the Ottoman Empire, the original church/mosque building was demolished and the current, larger church was built.

[2] It was built to some extent to mimic the design of the Hagia Sophia in the imperial capital Constantinople (now Istanbul), with the external vaults facing north and south, which are rare to find in many Orthodox churches in Greece.