[4] Under American Academic Health System, Hahnemann's financial condition worsened, with the hospital losing roughly $3 million a month.

[5] Joel Freedman, CEO of American Academic Health System, publicly stated that Hahnemann was on the brink of closure unless it found financial support from Pennsylvania or Drexel University College of Medicine.

[6] As a way to stem ongoing losses, American Academic Health System laid off hundreds of employees throughout 2018 and 2019, closed outpatient offices, and eliminated clinical services.

[8] On June 26, 2019, American Academic Health announced that because of unsustainable financial losses, Hahnemann Hospital would close in September 2019.

In March 2020, public health authorities attempted to reopen the hospital to provide additional beds during the COVID-19 pandemic.

After the completion in 1928 of what is now its South Tower, with its art-deco front doors facing Broad Street, Hahnemann moved one block east to its current location.

[13] In the 1960s and 1970s Hahnemann Medical College and Hospital was home to NSF-funded summer science educational programs for high school students interested in medicine and other scientific areas.

The North Tower housed Hahnemann's emergency department, trauma center, patient care floors, and other core services.

[17] On August 3, 2000, former US President Gerald R. Ford was admitted to Hahnemann Hospital after suffering minor strokes while attending the 2000 Republican National Convention.

[18] After divesting or closing all legacy Allegheny Health Education and Research Foundation hospitals, Tenet entered into a definitive agreement to sell its remaining Philadelphia assets — Hahnemann and St. Christopher's — to American Academic Health System, a newly formed affiliate of Paladin Healthcare.

In 1993, the college became the first medical school in the country to completely integrate women's health issues into its curriculum instead of an occasional lecture or optional elective.

[27] Hahnemann University Hospital's façade has appeared in numerous TV shows, including It's Always Sunny in Philadelphia, The League, Cold Case, NCIS: Los Angeles and The Mindy Project.