The hospital provides comprehensive pediatric specialties and subspecialties to pediatric patients aged 0–21[2] throughout eastern Pennsylvania and is one of the oldest full-service hospitals in the United States totally dedicated to the care of children.

[3] On November 30, 1875, founder William H. Bennett, MD, opened St. Christopher's Hospital as a charitable ambulatory pediatric clinic.

St. Christopher's Hospital for Children operates several satellite offices throughout the Greater Philadelphia region and southern New Jersey.

Each year St. Christopher's Hospital for Children receives thousands of applications to its Pediatric Residency Program from which 300 are selected to interview.

[12] Pediatric services include sub-specialties such as cardiology, endocrinology, gastroenterology, nephrology, neurology, pulmonology, oncology, and rheumatology.