In this role, Mohammad Hossein invested heavily in agriculture, which increased his own wealth and contributed to Isfahan's economic revival.
In 1806 he was appointed mostowfi ol-mamalek, given the title Amin ol-Dowleh, and his son, Abd ol-Hossein Khan Isfahani succeeded him as beglarbegi.
In 1818, Mirza Shafi Mazandarani died and Mohammad Hossein was appointed to the position of sadr-e a'zam which he held until his death in 1823.
He removed the famous clock on the Naqsh-e Jahan, rebuilt parts of the Safavid Haft Dast palace and renovated the Bagh-e Anguristan, the Hasht Behesht, and the Talar-e Tavila.
[3] Mohammad Hossein's son, Mohammad Ibrahim Khan Nazir ol-Dowleh, married one of the Fath Ali Shah Qajar's daughters (Khadijeh Soltan Begom, "Esmat-ed-Dowleh)[4] and Khan's daughter married Husayn Ali Mirza Farmanfarma, governor of Shiraz.