After working alongside Brian Cox and Ian McKellen at the Royal National Theatre, Kae-Kazim began appearing on British television in episodes of The District Nurse, The Bill, Saracen, Screen One, and Love Hurts.

[4] He made his feature film debut in Ross Kettle's After the Rain (1999) alongside Louise Lombard and Paul Bettany.

Following the success of Hotel Rwanda, Kae-Kazim went on to appear in the films Slipstream alongside Sean Astin and The Front Line before playing Captain Jockard in Pirates of the Caribbean: At World's End.

[7] Kae-Kazim made guest appearances in the likes of Lost, Law & Order: Special Victims Unit and Criminal Minds.

[4] He joined the cast of the Fox series 24 as Colonel Iké Dubaku for its 2008 tie-in television film 24: Redemption and its 2009 seventh season in 2009.

He also appeared in the BBC America adaptation of Terry Pratchett's The Watch and the Sky One series Intergalactic, as well as the films Black Beauty, The Shuroo Process, and Godzilla vs. Kong.

In January 2022, it was announced he would make his directorial debut with the upcoming feature film It’s the Blackness, set in South London where Kae-Kazim grew up.

Speaking about his role as ambassador, Kae-Kazim said: "I am truly honoured to be associated with Africa 2.0 – a pioneering platform for a new generation of African leaders to inspire and create a solid infrastructure- to shape a brighter future for our continent".