In October 2021, Amos announced his retirement from professional rugby union to focus on his medical career.

Amos made his debut for the Newport Gwent Dragons against Wasps in the Anglo-Welsh Cup on 22 October 2011, aged 17 years and 28 days.

[1] In doing so, Amos broke the record for the youngest player to play Welsh regional rugby held by Kristian Phillips of the Ospreys.

[2] In October 2021, Amos announced that he would be retiring from professional rugby union at the end of the 2021–22 season, at the age of 27, to focus on his medical career.

In April 2018, Amos was selected as a member of the Commonwealth Games squad to play in the Gold Coast for the Wales Rugby Sevens team.

Alongside Shane Williams and Gareth Thomas, Amos is one of only three Welshmen to have scored international Test tries against New Zealand, South Africa, Australia and Argentina.