In 2006, according to the statistical office of Hamburg and Schleswig-Holstein, Hamburg-Mitte has a total area of 107.1 square kilometres (41 sq mi).

Hamburg-Mitte consists of the quarters Billbrook, Billstedt, Borgfelde, Finkenwerder, HafenCity, Hamburg-Altstadt, Hamburg-Hamm, Hammerbrook, Horn, Kleiner Grasbrook, Neustadt, Neuwerk, Rothenburgsort, St. Georg, St. Pauli, Steinwerder, Veddel, Waltershof and Wilhelmsburg.

The historic center of Hamburg lies within the districts Altstadt, Neustadt and HafenCity, also defined by being inside the Wallring.

The facilities of the Port of Hamburg are located mostly in Hamburg-Mitte in the quarters of Kleiner Grasbrook, Steinwerder, Veddel, Waltershof and Wilhelmsburg.

The offices are responsible, among other things, for the application for a residence permit for purposes of study after entering the country.

The borough is serviced by the rapid transit system of the city train and the underground railway with several stations.

The central station Hamburg Hauptbahnhof is also for long-distance passenger trains for the German railway company.

According to the Department of Motor Vehicles (Kraftfahrt-Bundesamt), in the Hamburg-Mitte borough 66,831 private cars were registered (290 cars/1000 people).