Sir Charles Hamilton Sound, which has been shortened to and is more commonly known as Hamilton Sound, is a body of water on the northeast coast of the island of Newfoundland, between Fogo Island and the mainland to the south, and including (from west to east) Dog Bay, Gander Bay, and Rocky Bay.

At the east end of Hamilton Sound lie the Wadham Islands.

The native peoples of Newfoundland, the Beothuk, are presumed to have used the Gander River to gain access to the rich bird population on the many islands that dot Hamilton Sound.

By the late 1700s the salmon fishery was very well established and operated by Trinity-Poole merchants such as Benjamin Lester and Thomas Street.

The many communities in and around Hamilton Sound were largely settled in the period from 1840 to 1870 by settlers from Fogo in the western section, and in the eastern section, in communities such as Musgrave Harbour, settlers arrived from the Bonavista Bay and Conception Bay areas.