Hammerbrook (German pronunciationⓘ) is a quarter (Stadtteil) in the Hamburg-Mitte borough of the Free and Hanseatic city of Hamburg in Germany.

The name Hammer Brook originally referred to the entire area east of the city and north of the Bille extending as far as Horn.

From the 15th century onward it was administered by a Hamburg Senator as the Landherrenschaft (Lordship) of Hamm and Horn.

The current quarter of Hammerbrook was administratively created in 1938 under the Greater Hamburg Act, although a section in the east became part of the then Hamm-Süd (South Hamm).

Otto Stolten [de], elected from the district in 1901, was the first Socialist member of the Hamburg Parliament.

[6] In the Operation Gomorrah air raids Hammerbrook was the most completely destroyed section of Hamburg.

[8] 36% of the residents of the district were killed,[3] and the part west of Heidenkampsweg, which had been more than 90% destroyed, was initially closed off as a 'no-go zone' to prevent further injuries from falling masonry.

The city set aside the now largely open area for commercial uses,[11] but businesses built office blocks.