The museum contains a collection of archeological artifacts from the Nodena site, which is a former Native American village on the Mississippi River between 1400 and 1650.

Around 1400-1650 CE an aboriginal palisaded village existed in the Nodena area on a meander bend of the Mississippi River.

[4][5] The museum documents the culture of the civilization of the Nodena people, who lived in a 15-acre (6.1 ha) palisaded village on a horseshoe bend of the Mississippi River in the Wilson, Arkansas area.

Cultivation of crops, hunting, social life, religion and politics of that ancient civilization are topics of the exhibition.

[5][6] In 1900 James K. Hampson documented the discovery of a prehistoric mastodon skeleton 2 mi (3.2 km) south of the Nodena site.