Hamza Mirza (Persian: حمزه میرزا, romanized: Ḥamza Mīrzā; 4 September 1568 – 6 December 1586) was the Safavid crown prince of Iran during the reign of his father Mohammad Khodabanda (r. 1578–1587).

[1] He was born on 4 September 1568 (11 Rabi al-Awwal AH 976) in Herat was named after Muhammad's uncle Hamza.

His mother's murder on 26 July 1579,[3] Hamza became a central figure in conflict between Ali-Qoli Khan Shamlu and his Shamlu–Ustajlu coalition who favored young Abbas against reigning shah Khodabanda.

However assassination of Amir Khan Mawsillu-Turkman, governor of Azerbaijan, allegedly under orders of Hamza Mirza - according to Hamza, Amir Khan obstructed his efforts to identify those responsible for his mother’s murder - caused a rift among the Qizilbash tribes.

[1] Upon learning of the Ottoman forces' approach to Tabriz, Hamza Mirza requested help from the Takalu and Turkman tribes.

[6] For unclear reasons Hamza Mirza was stabbed to death in the Karabakh on the night 6 December 1586 in his camp by his own personal barber and was buried in Ardabil.