After the arrival of Osman Hafiz Pasha in Shkodër he resigned and opposed the newly established Ottoman administration.
[3] When in 1835 Hafiz Pasha ordered the arrest of all opposing elements, Hamza Kazazi opened fire to the patrol that came for him which triggered the uprising.
[4] Kazazi was member of the provisory council and leader of the military activities during the Albanian Uprising of 1835 against the Ottomans.
He was in charge of the uprising until 29 July 1835, when he was heavily wounded in the battle of a nearby place called "St. John's Stone" (Alb: Guri i Shëngjonit).
With the oppression of the uprising he completely left the political scene and regardless of the Ottomans' attempts to reengage him, he did not accept any positions until his death in 1859.