The second season of the black comedy slasher television series Scream Queens aired on Fox.

Emma Roberts, Abigail Breslin, Billie Lourd, Lea Michele, Keke Palmer, Niecy Nash, Glen Powell, Oliver Hudson and Jamie Lee Curtis reprise their roles from the previous season.

John Stamos, Taylor Lautner, James Earl and Kirstie Alley were added to the main cast.

Cathy then casts two doctors — Dr. Cassidy Cascade and Dr. Brock Holt — to fulfill the mission of the hospital, and installs Zayday Williams and the Chanels as medical students.

In June 2016, John Stamos, Taylor Lautner and James Earl joined the cast of the series, portraying doctors and an employee at the hospital, respectively.