She creates video blogs and informational content which is mostly based around relationships, sex and sexual health; liberation and welfare issues; literature; and travel.

[2][3] Witton's debut book, Doing It, concentrating on sex and relationships, was released for European readers on 6 April 2017 and in the US on 3 July 2018.

Witton's video History of Homosexuality was a 2013 finalist in The Guardian and Oxford University Press Very Short Film competition.

[15] Witton started her second YouTube channel, "More Hannah", at the end of 2019 to post lifestyle and productivity content.

Her main channel has featured series like The Hormone Diaries where she documented her fertility journey in trying to conceive.

On 5 December 2023, Witton posted a video on her main channel announcing she was going to quit producing sex education content.

[20] Her second book, The Hormone Diaries: The Bloody Truth About Our Periods, covering experiences of menstruation and education around it, was released in June 2019.

[22] The podcast follows an interview format where Witton invites a guest to talk about a topic where they have expertise, in conversation.