Hannington Bugingo was born 12 May 1981 at Mengo Hospital in Kampala, Uganda to Charles Bafakuleka Mwebaze,[1] a reverend, and Ruth Nakate, a businesswoman.

When they went back to Kampala, Bugingo, together with Phillip Luswata, Kwezi Kaganda, Farouq Twesigye, Frobisha Lwanga, Faith Kimuli, and Julius Lugaya met and formed Theatre Factory.

[4] In 2006, Bugingo acted as the Minister of Health's bodyguard in The Last King of Scotland [citation needed], starring Forest Whitaker and Kerry Washington.

[9] It was during this time that Bugingo won a bronze medal with Metropolitan Republic at The Loerie Awards for the MTN SIM card registration campaign.

"The project, meant to encourage youths to 'stand up' (Situka) for their rights, think of the future...is a story that covers the entire country, Africa, and the globe".

[15] In January 2019, the government of Uganda proposed a bill suggesting every artist should be registered under the Ministry of Gender, Labour and Social Development.

"[16] In February 2019, The Uganda Comedians Association (TUCA) was formed and Bugingo was elected as the founding president, while promising to wipe out vulgarity from the comedy industry.

[17][2] As TUCA head, he wrote to president Yoweri Museveni to push for enforcement of copyright law to protect the works of Ugandan artists.