[1] For many years, Milde sang under the direction of Franz Liszt, notably creating the role of Telramund in the world premiere of Richard Wagner's Lohengrin under his baton.

He sang in several other notable premieres, including singing the role of the High Priest in the first stage performance of Camille Saint-Saëns's Samson et Dalila in 1877.

In 1852 von Milde portrayed Fieramosca in the premiere of Liszt's revised version of Hector Berlioz’s Benvenuto Cellini and his wife sang the role of Teresa.

The couple also notably sang in the world premieres of Heinrich Dorn's Die Nibelungen on 22 January 1854, Franz Schubert's Alfonso und Estrella on 24 June 1854, Peter Cornelius's Der Barbier von Bagdad on 15 December 1858 and Cornelius's Der Cid in 1865.

Their son Franz published a biography about his parents (Ein ideales Künstlerehepaar, Rosa und Feodor von Milde.