In 1950 he started his training in gynecology at the Women's Clinic at Wuppertal under the directorship of Karl Julius Anselmino and advanced to become Oberarzt in 1954.

In 1966 he became Director of Gynecology at the City Hospital of Konstanz and in 1983 he was named Professor at the Freiburg University.

[1] In 1951, Frangenheim observed an internist performing a liver laparoscopy using a method developed by Heinz Kalk.

[1] In 1955 Frangenheim visited Raoul Palmer in Paris another pioneer in laparoscopy applying it for the investigation of infertility.

[3] Along with Palmer Frangenheim introduced a laparoscopic method to block the fallopian tubes for sterilization.