Hans Victor Westerhoff (born 14 January 1953)[2] is a Dutch biologist and biochemist who is professor of synthetic systems biology at the University of Amsterdam[4] and AstraZeneca professor of systems biology at the University of Manchester.

[7] At the beginning of his career Westerhoff worked in the area of non-equilibrium thermodynamics in relation to biological energy transduction.

[10] After being a coauthor of one of the first experimental papers to stimulate interest in metabolic control analysis[11] and participating in the group that proposed a harmonized terminology,[12] Westerhoff moved progressively towards working on multi-enzyme systems as his major activity, starting with an analysis of the effect of enzyme activity on metabolite concentrations.

[13] He published many papers in this area, of which one may note an analysis of the control of regulatory cascades,[14] analysqis of glycolytic oscilations in yeast,[15] and showing that the in vivo behaviour of Trypanosoma brucei agreed with the kinetic properties of the glycolytic enzymes.

[16] Westerhoff and colleagues discovered magainin in the African clawed frog which helps it fight against bacteria.