[5] In Happy-Go-Lucky, Sedaris continues where he left off in Calypso, writing about his transition into late midlife during the final years of the first Trump administration and into the COVID-19 pandemic.

He writes about his life and the lives of his family—including his siblings, his longtime partner Hugh, and the decline of his 98-year-old father, with whom he had a fractured relationship.

Happy-Go-Lucky debuted at number one on The New York Times nonfiction best-seller list for the week ending June 4, 2022.

"[8] In a rave review, Anita Snow of the Associated Press wrote, "Writing about his teen years, Sedaris is simultaneously amusing and brutal while unflinchingly exposing the ironies of his family and life in general.

"[9] In a mixed review, Houman Barekat of The Guardian criticized Sedaris as coming across as "glib on racial politics", "cranky" toward the younger generation, and "petty" and "bitter", but admitted "it is partly because of these flaws that people relate to him."