His wife Amenhotep bore him three sons Djehutjmes-machet, User-pechtj, and Aa-cheper-ka-ra-nefer (who was High Priest at the Mortuary Temple of Thutmose II, lector priest) and 4 daughters Henut, Henut-nefert (a singer of Amun), Sen-seneb, and Ta-em-resefu (also a singer of Amun).

[5] Only a few "monuments" of Hapuseneb have survived, his tomb TT67, shrine No.15 at Gebel el-Silsila, 3 funerary cones (Corpus-No.

Beyond that Hapuseneb is also mentioned on the statue of Hapu (Turin 3061), the statuette of the steward Amenemhab (Cairo CG 42112), and in an inscription in the tomb of Userhat; TT51, Sheikh Abd el-Qurna.

Among other things Hapuseneb, High Priest of Amun, was responsible for the building of a ship, a gate, a shrine, for the production of temple equipment, door wings and buildings - and he was the "Overseer of the construction of a royal tomb" but it is not clear whether he was responsible for KV20 or the rock tomb of Hatshepsut.

Hapuseneb was the first HPA to also hold the title of Overseer of the hem priests of Upper and Lower Egypt.