Harbor Isle is a hamlet and census-designated place (CDP) in the Town of Hempstead in Nassau County, New York, United States.

In the 1950s, a proposal was made for Harbor Isle to be annexed by the adjacent village, Island Park.

[2][3][4] The proposal ultimately was defeated, and Harbor Isle remains an unincorporated hamlet to this day.

Full-time, year-round male workers had a median income of $70,833 versus $44,792 for the same category of females.

Harbor Isle, in its entirety, is located in the Island Park Union Free School District.