Harding is a member of the Minnesota State High School League and the athletic teams compete in the Saint Paul City Conference.

While academic performance has improved over the past few years, there was not enough data to associate the increase with smaller learning communities.

In 2009 the music listening team made up of Matt Howard, Maivboon Vang, and Colton Moyer, took home a second-place finish at the state competition, this was after placing first in sections.

[3] One student from the class of 2006 was the recipient of the Gates Millennium Scholarship, five Harding alumni were named KARE-11 Academic All-Stars[4][5][6] and one received a WCCO-TV outstanding graduate award.

In the spring of 2002, Sheila Emms broke the Minnesota single season record for strikeouts as a high school fastpitch softball pitcher.

Following her high school career she was offered a full tuition scholarship to pitch for Illinois State University.

Other sports include soccer, tennis, swimming, cross-country, baseball/softball, Nordic skiing, basketball, hockey and golf.

Its chief rival is Johnson Senior High School, also located on the east side of Saint Paul.

[8] 15-year-old Devin Denelle Edward Scott was stabbed in the chest and abdomen by 16-year-old Nosakhere Kazeem Holmes following a fight between the two in a school hallway.