He made over 180 appearances and scored over 70 goals for the club, winning the Bola de Prata for top scorer as the team won the Primeira Liga in 2018–19.

A full international since 2013, Seferovic represented Switzerland at the FIFA World Cup in 2014, 2018 and 2022, and the UEFA European Championship in 2016 and 2020, earning over 90 caps.

[13] On 11 July 2013, Seferovic completed a move to Spanish La Liga club Real Sociedad on a four-year contract for a €2 million transfer fee.

[16] Four days later, he scored a volley as Real Sociedad beat Lyon 2–0 away from home in the play-off qualification round for the 2013–14 UEFA Champions League.

[19][22] He arrived with comparisons to Darko Kovačević, a league runner-up with Real Sociedad in 2003, but did not capitalise on his early goals to cement a spot in the team.

"[24] He made his debut on 16 August, scoring the opening goal in the ninth minute as Frankfurt defeated fourth-tier Viktoria Berlin 2–0 away in the first round of the DFB-Pokal.

[35][36] Despite starting the 2018–19 season as the fourth attacking option of manager Rui Vitória, Seferovic became the team's top scorer on 11 January 2019, under the guidance of Bruno Lage.

[41] Internationally, he scored yet another winner, this time in a 2–1 win over Galatasaray in the UEFA Europa League round of 32 on 14 February, helping Benfica seal their first victory in Turkey.

[45] The following year, with the Brazilian loaned to Tottenham Hotspur, Seferovic returned to the forefront and scored 22 goals, one fewer than top scorer Pedro Gonçalves of Sporting.

[58] In 2013, ahead of the Bosnia and Herzegovina national team's match against Slovenia, Seferovic claimed he wanted to play for the country of his parents' birth.

[59] However, he later accepted a call-up from Switzerland, and made his debut in a friendly against Greece on 6 February 2013, where he replaced Mario Gavranović for the last 20 minutes of the 0–0 away draw.

[60] On his third cap, on 8 June 2013, he replaced Josip Drmić for the last 15 minutes, and in injury time, scored the only goal of a home 2014 FIFA World Cup qualifier against Cyprus.

[64] In qualification for UEFA Euro 2016, Seferovic scored three goals, including two in the first half of a 4–0 win away to San Marino that was Swiss' first victory of the campaign.

[68] On 18 November 2018, Seferovic scored a hat-trick as the Swiss came from 0–2 down to defeat Belgium 5–2 in the UEFA Nations League to top their group and qualify for the finals.

[73][74][75] Seferovic's family is from Sanski Most, Bosnia and Herzegovina (then in SFR Yugoslavia); his parents Hamza and Šefika Seferović immigrated to Switzerland in the late 1980s.