Harlem River Drive is a 4.20-mile (6.76 km) controlled-access parkway in the New York City borough of Manhattan.

South of the Triborough Bridge, the parkway continues toward lower Manhattan as FDR Drive.

The parkway north of 165th Street was originally part of the Harlem River Speedway, a horse carriage roadway opened in 1898.

The parkway crosses under 125th Street alongside the Harlem River, where exit 18 leads off the northbound lanes to the Willis Avenue Bridge before bending to the northwest.

Harlem River Drive proceeds northwest, crosses under the Third Avenue Bridge, reaching exit 21 northbound, a junction for 135th Street.

The four-lane arterial continues north through Manhattan, entering a junction with Dyckman Street and Tenth Avenue, which is the northern end of Harlem River Drive.

[6] Originally, the Speedway was exclusively for the use of horse-drawn carriages and those on horseback; bicyclists were specifically excluded, as were sulkies and drays.

[20] In 2003, the New York State Department of Transportation ceremonially designated the parkway as the "369th Harlem Hellfighters Drive" in honor of the all-black regiment that fought to defend France during World War I.

[21] In April 2010, the Manhattan Waterfront Greenway runs between the river and the drive, from 155th to Dyckman Streets, in a portion of Highbridge Park which had been abandoned and fenced off approximately half a century.