[7][8] In January 2016, it was announced that Smith will play her father's character's daughter in the half-hour comedy Hollyweed.

[10][11] Smith joined John Barrowman and other co-hosts in the debut September 15, 2018 episode of DC Daily, a discussion show focusing on DC Universe comic topics[12][13] In early 2019, Smith rejoined her father's View Askewniverse, playing Millennium "Milly" Faulken in Jay and Silent Bob Reboot.

According to Kevin Smith, Milly is part of a girl-gang (made up of characters played by Aparna Brielle, Treshelle Edmond, and Alice Wen) that is not unlike the girl-gang of Jay and Silent Bob Strike Back; however, their goals and motivations are different, and they were put together as a commentary on Hollywood's use of youth and diversity in reboots and sequels.

[14] She also had a small role in Quentin Tarantino's Once Upon a Time in Hollywood, portraying a member of the Manson Family.

[15] Smith is good friends with and a frequent co-star of Lily-Rose Depp and actress Aparna Brielle.