It is set at Kevin Smith's comic book shop, Jay and Silent Bob's Secret Stash, in Red Bank, New Jersey.

Filmmaker Kevin Smith was drawn to television through his love of podcasting, through which he says he realized his true calling: telling stories with words rather than pictures.

[1] His website, SModcast.com, features a number of podcasts, including I Sell Comics!, hosted by Mike Zapcic and Ming Chen,[2] and Tell 'Em Steve-Dave!, co-hosted by Walt Flanagan and Bryan Johnson.

[15] It was also announced that guest cast member Robert Bruce would be the focus of a companion series that will follow him as he searches for collectibles at sales, auctions and flea markets across the country.

During the first season of I Sell Comics, some podcast episodes were pre-recorded during the filming of the show, while others were recorded live on the SModco Internet Radio station (S.I.R.)

"[28] Mike Hale of The New York Times opined that the series is an authentic portrayal of post-collegiate American life, and concluded, "It’s diverting, a little sad, a little boring, full of geeky macho posturing and ultimately pointless, much like a Wednesday afternoon in a comic-book shop.