Harmon and comedians Erin McGathy and Jeff Davis, along with game master Crittenden, play a fantasy roleplaying campaign in front of a live audience, while each episode features a special guest player.

With Beor carrying Fondue’s corpse, Lizzard and the party team up and head to the great hall of the castle where they find Celty hysterical with rage.

Fondue and Boneweevil insist on reviving her to defeat her over and over, irritating Lizzard to the point that he buffs her, makes her invisible, and gives her the control of his golem.

Prior to the creation of HarmonQuest, Harmon had included a Dungeons & Dragons-style segment, hosted by Crittenden, at the end of the weekly podcast Harmontown.

Unlike Critical Role episodes which are long-form, full-play D&D podcasts often exceeding 4hrs, HarmonQuest has been praised for its accessibility towards casual and beginner audiences.

Javon Phillips of The Los Angeles Times said, "The show makes its ventures a lot less time-consuming and ups the watchability quotient by throwing in animated segments in digestible half-hour episodes.