[4] This was highlighted by a winning the championship at the 2020 Australian Open where he defeated compatriot Arthur Cazaux in straight sets 6–4, 6–1.

In singles, he was also defeated in the first round by veteran compatriot Gilles Simon in straight sets.

Pairing with Cazaux again, they were given a wildcard entry into the main doubles draw of the 2020 French Open but would again be defeated in the first round by Łukasz Kubot and Marcelo Melo in straight sets.

At the same tournament Mayot received also a wildcard into the singles main draw, and was defeated by Alejandro Davidovich Fokina.

In July, Mayot reached his first ATP Challenger Tour final as a qualifier at the 2022 Tampere Open in Finland, losing against Zsombor Piros.

In June, Mayot won his first doubles match at the 2023 French Open partnering with Jonathan Eysseric, having failed to qualify in the singles.

At the 2024 Open Sud de France, he reached the quarterfinals defeating two compatriots Lucas Pouille and Benoît Paire.

He made his Masters debut at the 2024 Miami Open after qualifying into the main draw with wins over Arthur Cazaux by retirement and David Goffin.