[4] He took the role of Link in The Matrix series after the original operator Tank was written out of the script when Marcus Chong was fired over monetary disputes.

[5] Lost co-star Adewale Akinnuoye-Agbaje starred with Perrineau on the HBO series Oz.

Perrineau has also done live shows where he performs with a full band: two guitars, bass, drums and keyboards.

He was cast to play the character of Damon Pope, the main antagonist of season 5 of the hit show Sons of Anarchy.

[11][12] Perrineau starred as Stevie, the bass player, in the TBS comedy Wedding Band, which ran from 2012 to 2013.

[citation needed] He made his Broadway debut in the Roundabout Theatre Company production of Anton Chekov's The Cherry Orchard, adapted by Stephen Karam.

From 2017 to 2022, Perrineau played Dean, a man on the autism spectrum and the brother of Desna, in TNT's Claws.

[citation needed] In November 2022, Harold Perrineau signed with Independent Artist Group for representation.