In 1994, he returned to sports, as co-star of Major League II, taking over the role of center fielder Willie Mays Hayes from its originator, Wesley Snipes.

He won the best actor award at the Monte Carlo Television Festival for portraying Kingsley Ofusu in this true story about the plight of undocumented African stowaways hoping to reach America.

[5] In his network television debut, Epps guest starred as Dr. Dennis Gant, a surgical intern struggling with depression, on the hit medical drama ER for several episodes in its third season.

[6] After his television work on ER, Epps returned to film in 1997 with a role as a giddy moviegoer, on a date with a woman played by Jada Pinkett Smith, who ends up an early victim of a psychopathic slasher in the blockbuster sequel Scream 2.

[7] Also in 1997, Epps starred in the fact-based HBO movie First Time Felon as a small-time criminal who goes through Chicago's boot camp reform system and undertakes a heroic flood rescue, only to be faced with the adjustment of re-entering society with the mark of ex-con.

[8] While The Mod Squad proved a critical and box-office bust, Epps's later 1999 effort The Wood offered him a serious and multi-dimensional role as Mike Tarver, narrator and lead of this critically-acclaimed coming-of-age ensemble comedy.

[9] Following a group of middle-class African Americans from youth to adulthood, the debut effort from director-screenwriter Rick Famuyiwa co-starred Richard T. Jones and Taye Diggs.

[8] Also in 1999, Epps was featured alongside Stanley Tucci and LL Cool J, playing an undercover detective who finds himself caught up in the illegal goings-on he is investigating in In Too Deep.

In 2004, Epps played drug-dealer-turned-prizefighter Luther Shaw who falls under the tutelage of boxing promoter Jackie Kallen (Meg Ryan) in the film biopic Against the Ropes.

In 2022, it was announced that Epps would star in the Lee Daniels-directed supernatural horror The Deliverance alongside Mo'Nique, Andra Day, Miss Lawrence, and Tasha Smith.