[5] Early in her adult life she worked as a book editor,[6] publishing The Best American Orations of Today (1903) and teaching drama and elocution at Galesburg High School in Illinois.
[2][7] Blackstone moved to New York in 1903 to study art at the Pratt Institute, where one of her teachers was William Merritt Chase.
[6] She spent part of World War I in New Mexico working for the U.S. government, which tasked her with painting Native Americans and their environments.
"[6] Among those she painted were soprano Amelita Galli-Curci,[10] singer Nadezhda Plevitskaya, architect D. Everett Waid, pianist Stell Andersen, Mrs. Frederick D. Underwood, Mrs. Andrew MacLeish, Mrs. John G. McCullough, and numerous midwestern businessmen and their wives and children.
[7] Her papers (1870-1984) are held by the Archives of American Art of the Smithsonian Institution and include business documents, sketchbooks, artwork, photographs, correspondence, and an unpublished biography by writer Esther Morgan McCullough.