In 2006, he graduated from Emerson College, where he was a member of Sigma Alpha Epsilon, with a degree in television and video production.

[6] In 2012, Wittels was cast as a co-star in Sarah Silverman's NBC pilot Susan 313 along with June Diane Raphael and Tig Notaro, which was not picked up.

He was also part of the popular series of CBB episodes entitled "Farts and Procreation" along with fellow Parks and Recreation alumni Adam Scott and Chelsea Peretti.

There were four "Farts and Pro" episodes, the final one being recorded very shortly before Harris' death and released days later, posthumously.

[12] In August 2013, NBC picked up an untitled Wittels sitcom, about a slacker still living with his parents while dealing with his whiz kid younger brother, a multi-millionaire entrepreneur in high school.

[19] In an interview on the podcast You Made It Weird dated November 19, 2014, Wittels openly discussed his personal life and history of drug addiction with host Pete Holmes.

He said he began to rely on oxycodone to deal with his stress over the relationship, his work on various television pilots, and writing the Humblebrag book.

During the episode, which was released nearly a year after the show, Wittels touched on the impact his addiction had on his personal and professional life, as well as the use of recreational drugs as part of his Phish fandom.

[22][23] Following news of his death, Wittels' friends and colleagues—including Aziz Ansari, Amy Poehler, Dan Harmon, Sarah Silverman, Doug Benson, and Scott Aukerman—paid tribute to him.

[24][25] Ansari wrote on his blog that the two had been planning to move to New York City together in March,[26] and he shared his favorite memory of Wittels during an appearance on Conan.

"[28] Similarly, a frame, "Dedicated to the Memory of Harris Wittels", appears before the closing credits on the Aziz Ansari: Live at Madison Square Garden comedy special that was released March 6, 2015, on Netflix.

In the first-season finale of Ansari and Alan Yang's show Master of None, on which Wittels was a writer, an intertitle states "This series is dedicated to the memory of our dear friend.

[29] Harris' sister, Stephanie Wittels Wachs, used funds her brother left her in his will to set up a multi-discipline performance and communal space for creative people[clarification needed] in Houston.

On April 20, 2017, the first 420-themed "Harris Phest" was held, with comedy, Parks and Rec sketches, and a Phish cover band to mark what would have been his 33rd birthday.