[2] While initially focusing on interviews with comedians, an increasing number of guests from other fields have appeared on the show, including musicians, pastors, scientists, and authors.

The show is usually recorded in-studio at the Nerdist studio at Meltdown Comics in Los Angeles, California.

Since March 21, 2012, Holmes has recorded multiple live episodes of the podcast, including in Austin at South by Southwest,[3] New York,[4] Bloomington,[5] Chicago,[6] Montreal, Quebec, San Francisco, Los Angeles at the LA Riot Festival, and Toronto at Just For Laughs.

Club interview, Holmes listed his favorite guests as Emily Gordon and Bert Kreischer.

Harris Wittels described his long battle with addiction and his newfound sobriety just months before his death in February 2015.