Harrisburg is a village in western Boone County, Missouri, United States.

It is named in honor of John Woods Harris, an early county leader and owner of the nearby “Model Farm” on Thrall’s Prairie.

Harrisburg was named for John W. Harris,[4] who inherited the Model Farm on what was Thrall's Prairie, the first permanent settlement in the county.

The small Prewitt Family Cemetery is located behind Harrisburg Elementary School.

The much larger Harrisburg Cemetery is located at the East end of town.

[5] Reverend Green Carey preached at the Bethlehem Baptist church a few miles south of Harrisburg for fifty years and claimed to have joined more than five hundred couples in marriage.

[5] The first church building in town belonged to the Harrisburg Christian congregation.

[7] Harrisburg is located on Missouri Route 124 about one mile from the Boone-Howard county line.

Perche Creek flows past two miles east of the community.

[11] In 2006 and 2008 the Harrisburg boys basketball team won the Missouri Class 2A state championship, then in 2010 and 2012 Harrisburg won the Missouri Class 2A girls basketball state championship.

25.7% of all households were made up of individuals, and 10.9% had someone living alone who was 65 years of age or older.

About 12.0% of families and 18.0% of the population were below the poverty line, including 28.8% of those under the age of eighteen and 25.0% of those 65 or over.