[1] They joined the Eastern Colored League (ECL) for the 1924 season with Hall of Fame center fielder Oscar Charleston as playing manager.

The Giants became known primarily for their hitting; along with Charleston, outfielder/first baseman Heavy Johnson, winner of the batting triple crown for the 1923 Kansas City Monarchs, was signed away from the rival Negro National League.

The club dropped out of the ECL in 1928 and intended to play an independent schedule, whereupon most of its best players signed with other teams leading Strothers to disband the Giants.

After Colonel Strothers' death in 1933, there were several other black professional “Giants” teams representing Harrisburg, but baseball slowed as World War II arose in the 1940s.

By the next year this version of the Giants were an inaugural team of the new Eastern Negro League, where they won the title with a 16-6 season.