[1] With the guidance of his brother Johnny, Harry Broome's professional fighting career began on 11 October 1843 when he defeated Fred Mason at Northfleet, Kent, for a total purse of £100, £50 per side.

One source quoted his weight, likely with accuracy, as only 136 pounds or 9 st 10 lb (62 kg), a light welterweight, and his age as barely eighteen.

[8][3] Broome's career reached a peak in 1851 when, fighting above his weight, he defeated William Perry, the "Tipton Slasher".

[10][8] The outcome of this fight enabled Broome to claim the title of heavyweight champion of England, and take the championship belt.

[1][11][3] Broome defended the heavyweight championship of England only once successfully against Henry Orme on a warm 18 April 1853, winning in a thirty-one round fight in Brandon, Suffolk, that lasted 2 hours, and eighteen minutes.

[4][1][13][14][3] In August 1853, Broome wrote to Bell's Life in London and Sporting Chronicle announcing his retirement from boxing and that he was pulling out of an agreed re-match with William Perry.

[1] On his second defense of the English title, Broome lost a fifty-one round match to Paddock at Bentley in Sussex on 19 May 1856, in Manningtree, England in one hour, three minutes.

To avoid the police, the spot found for the fight was on a piece of meadow ground in a hollow where the contestants and supporters could scarcely be seen.

After being released from hospital care, he died in poverty due to his medical expenses, on the evening of 2 November 1865 at his residence on 30 Frith Street, in London's Soho.

He was buried in Norwood Cemetery in the same tomb as his brother, Johnny Broome, requiring patrons to pay the sum of £4 for the burial.