Kargman is founder and CEO of Kargo Global, Inc., a firm that manages mobile brand advertising for many media companies including CBS Interactive, Hearst, The Daily Mail, Meredith, Scripps, Target Corporation, T-Mobile, Vice, and Vox.

[11] Kargman initially founded Kargo Inc. in 1999,[11] hoping to build software that would serve as the mobile web's foundation.

[12] However, because the company was Tribeca-based and within the 9/11 impact zone, Kargo received approximately $70,000 from New York City's World Trade Center Business Recovery Grant Program, which kept it afloat.

So, after watching media companies be unable to sell mobile adds for several years, Kargman decided to move Kargo into the ad business.

[13] Kargo has locations in New York City, Chicago, Los Angeles, San Francisco, Detroit, Dallas, Sydney, and Auckland.

Kargman was also named Ernst & Young Entrepreneur of the Year 2016 New York in the Advertising Technology category[16] and one of Business Insider's Silicon Alley 100 in 2014.