Harry F. Powers (born Harm Drenth; November 17, 1892 – March 18, 1932) was a Dutch-born American serial killer who was hanged in Moundsville, West Virginia.

Sergio Aquindo's graphic novel Harry & the helpless children (2012) traces the killer's career and the fascination the case aroused in the press at the time.

After his 1931 arrest, police investigation using fingerprints and photographs revealed that he had been incarcerated for burglary under his birth name in Barron County, Wisconsin, in 1921 and 1922.

[4] Although not charged, Powers was suspected of involvement in the 1928 disappearance of Dudley C. Wade, a carpet sweeper salesman with whom he had once worked, and the unsolved murder of a Jane Doe in Morris, Illinois.

[5] Using the alias "Cornelius Orvin Pierson", Powers began writing letters to Asta Eicher, a widowed mother of three residing in Park Ridge, Illinois.

[7] Some time later, Powers courted Dorothy Pressler Lemke from Northborough, Massachusetts, who was also looking for love through lonely hearts advertisements.

Lemke did not notice that instead of sending her trunks to Iowa, where Powers claimed to be living, he sent them to the address of "Cornelius O. Pierson" of Fairmont, West Virginia.

[9] They found love letters, which led them to Quiet Dell, where "Pierson" lived under the name Harry Powers with his wife.

[3] Evidence and autopsy results showed that the two girls and their mother were strangled to death while the young boy's head was beaten in with a hammer.