In 1912 at the age of 24 he was made an associate of the Royal Institute of British Architects and went into partnership with Harold Seymore Scott, with whom he designed a cinema in Birchfield, completed in 1913,[4] and several upmarket houses in Warwickshire.

[6] On his demobilisation he set about re-establishing his architectural practice, but an affair with the wife of a neighbour resulted in a scandalous double divorce that destroyed his reputation, and he spent the following years in Leamington Spa working as a manager in the catering industry.

[3] Weedon returned to Birmingham and to architecture in 1925, quickly building up his practice designing housing estates and commercial and industrial premises.

[2] The practice's other major notable building of the era – the Villa Marina, an early British example of a house in the International Style built in Llandudno in 1936 – was designed by Weedon personally.

This resulted in a wide range of contacts with the Midlands' engineering and industrial firms and the post-war era saw the Weedon Partnership focusing on the design of factories, including notable work at the British Motor Corporation's Longbridge plant and in Cowley, Oxford, and a large factory for Typhoo Tea in Digbeth, Birmingham.

The Partnership is still in business as WeedonArchitects and celebrated its centenary in 2012 with a move to new offices in Harry's Yard in the Jewellery Quarter close to Birmingham City Centre.