Initially helping the Hendersons with Harry's care, and Sasquatch research, was Walter Potter, a biologist working for the Department of Animal Control.

Also seen early on were the Glicks, neighbors of the Hendersons; Samantha was a pretty, young single mother and reporter, and Tiffany was her precocious little girl, a classmate of Ernie's who had an obvious crush on him.

However, she did catch on to the fact that the family was hiding a bigfoot, and had several close encounters with Harry; fortunately, Darcy disappeared from the show before she could have exposed the secret about him.

For a while, Harry had to adjust to a high-profile life full of exhibition and additional scientific studies, but at the same time the entire family got used to resting more comfortably now that they did not have to hide the big creature from view anymore.

Reruns aired on digital subchannel Retro Television Network from August 2008 until their distribution agreement with NBCUniversal ended in June 2011.