[1] In Wethersfield, US 5 and Route 15 leave the turnpike for the controlled-access Wilbur Cross Highway heading towards Hartford.

[2] The turnpike was built to connect the courthouses of New Haven and Hartford in as straight a route as was allowed by the terrain.

Its southern terminus was at Grove Street,[2] which forms the northern boundary of the original nine squares of New Haven.

In 2010 a book entitled, The Berlin Turnpike: A True Story of Human Trafficking in America was published by author Raymond Bechard.

The long straight trajectory of the Berlin Turnpike has allowed it to become prone to excessive speeding and deadly accidents.