Established in 1868 and annexed in 1912, it is the city's northernmost neighborhood, centered roughly on the intersections of I-75 and Ronald Reagan Cross County Highway.

Its boundaries are a combination of Caldwell Park and Ronald Reagan Cross County Highway to the south, I-75 to the east, and a combination of Millsdale Street and Compton Road to the North.

[2] Hartwell was platted in 1868 by the Hamilton County Building Association.

It was named for John W. Hartwell, who was vice president of the Cincinnati, Hamilton and Dayton Railway when the station was located.

[2] According to the U.S. Census American Community Survey, for the period 2016-2020 the estimated median annual income for a household in the neighborhood was $52,396.