He built the Parker House, the first hotel in the United States "on the European Plan".
A few months later he bought out the owner, and in 1833 opened Parker's Restaurant in the basement of 4 Court Square.
In 1854, he built the Parker House hotel and restaurant, "an immense establishment of marble",[2] designed by architect William Washburn.
On November 16, 1882, a large public dinner was held in honor of Parker's 50 years in business.
A funeral was held at the Arlington Street Church; the facade of the Parker House was "heavily draped" in mourning.