N'dam N'Jikam won a silver medal in the middleweight division at the 2003 All-Africa Games, losing to Ramadan Yasser of Egypt in the final.

N'jikam represented Cameroon in the middleweight bracket at the 2004 Olympics, defeating Juan Ubaldo of the Dominican Republic and Andy Lee of Ireland on close countback decisions, but losing in the quarter-finals to eventual gold medallist Gaydarbek Gaydarbekov of Russia.

As one of the few professionals who entered, N'Jikam once again represented Cameroon and qualified for the light-heavyweight bracket, but lost in the first round to Michel Borges of Brazil.

On 30 October 2010, having fought mainly in his adoptive France, N'Jikam won the vacant WBA interim middleweight title with a close unanimous decision (117-111, 115-114, 115-114) over Avtandil Khurtsidze at the Palais des sports Marcel-Cerdan.

He won a wide unanimous decision (119-109, 119-110, 116-111) However, major controversy arose during the fight when N'Jikam was knocked out of the ring by a series of punches from Lorenzo in round five.

[9] He was later promoted to full world champion status on 25 August, after Dmitry Pirog was stripped of the title for choosing to fight Gennady Golovkin instead of mandatory challenger N'Jikam.

[10] In his first world title defence on 20 October, as well as his first fight in the United States, N'Jikam suffered six knockdowns en route to a unanimous decision loss (107-115, 107-115, 107-115) to Peter Quillin.

[16] The two judges who scored the fight for N'Jikam were immediately suspended and WBA president Gilberto Mendoza issued a public apology.